Now the big screens, popcorn stands and iconic movie posters have been replaced by a bingo hall.
To celebrate the historic building's rich history, staff at Mecca Bingo hosted a 70th anniversary party.
The club invited residents who were celebrating their own 70th birthday along to the event to enjoy glasses of bubbly, birthday cake, karaoke and charity raffles.
Bingo club manager, Graeme Ewart, said: "It's great to work in such a historic and striking building and when we found out it was approaching this amazing milestone we thought we'd celebrate.
"Some of our members remember visiting the Odeon when it was a cinema and concert venue and since announcing the birthday party I've heard some amazing stories from the last 70 years.
"It's great to think someone such as Dusty Springfield played her first solo gig here all those years ago."
On June 27, 1938 the Odeon, one of Halifax's super cinemas, opened on the corner of Broad Street and Orange Street.
The first film shown at the Odeon, which cost £59,727 to build, was The Perfect Specimen, starring Errol Flynn.
Seats ranged in price from 6d (2.5p) to 1/6d (7.5p).
The building has played host to stars such as Dusty Springfield and Cliff Richard and The Drifters in 1959.
But with the expansion of TV the cinema started to lose audiences.
The Odeon closed on October 18, 1975, the last films were Confessions of a Pop Performer and Police Story.
Three days later the cinema, which had been owned by the Rank Organisation, became a Top Rank Bingo Hall and later a Mecca Bingo Club.